CANCER
Research groups

Asbestos Diseases

Seeking to better understand the biology of mesothelioma for earlier diagnosis and more effective, personalised treatments.

Bowel Health

Identifying methods for earlier detection, improved surveillance and enhanced effectiveness of treatments for colorectal cancer.

Chromosomal Instability

Finding metabolic interventions that can leverage the chromosomal instability of cancer cells and lead to novel therapeutics.

Circular RNAs in Cancer

Investigating circular RNAs and how they are formed and regulated in cancer, human diseases and across stem cell differentiation.

Drug Discovery

Understanding the fundamental structural biology of biomolecular systems in cancer to develop new generation anti-cancer therapeutics.

Environmental control of cell growth and cell division

Shedding light on the mechanisms behind environmental and metabolic control of cell division and cell survival to identify novel targets for the treatment of human cancers.

Genetics and Epigenetics

Understanding the genetic basis of disease, from identification of inherited and somatic mutations through to dysfunctional epigenetic regulation of gene expression. 

Gene Expression

Exploring the genetic and epigenetic processes that are associated with colorectal cancer, in the expectation of identifying new anti-cancer treatments.

Human Neurophysiology

Developing cutting-edge technologies to better recreate conditions of the human brain in vitro.  We generate live human brain tissue that we can study extensively in the laboratory settings.

Immunomudulation

Investigating the immunology underlying human diseases including Type 1 diabetes, transplantation and cancer.

Lymphoproliferative Research

Exploration of haematological malignancies: chronic lymphocytic leukaemia, non-Hodgkin lymphoma and other lymphoproliferative conditions, with a particular interest in metabolomics, proteomics and molecular genomics of these tumours and their response to therapies.

Lymphoproliferative Research - Proteomics and Metabolism

Understanding the metabolic differences between chronic lymphocytic leukemia cells and healthy cells, and if these pathways can be targeted using novel therapies.

Metabolism and Cancer

Development of novel treatments for cancer and diabetes through understanding the basic mechanism by which insulin-like growth factors and insulin bind and activate their receptors to promote cell growth, survival and metabolic control.

Pharmacology

Exploring the role of specific metabolites and enzymes within the arginine metabolic pathways in the pathophysiology of disease states, particularly the enzyme dimethylarginine dimethylaminohydrolase 1 as a therapeutic target in cancer.

Neuro-urology

Identifying the functional classes of afferents that innervate the bladder, and the channels and receptors underlying their function in health and chronic pain states, to reduce bladder pain and disfunction following immunotherapy for bladder and prostate cancer.  

Microbiome and Host Health

Investigating the complex mediatory role of the human microbiome in acute conditions and chronic disease such as cancer.  

Molecular Pharmacology

Study of the mechanism that controls the initiation and progression of cancer and its response to drug treatment, with a focus on enzymatic control of small molecules within cells, including anticancer drugs and ligands that activate nuclear receptor signalling pathways.

Molecular Medicine and Genetics

Understanding the mechanisms that drive the survival and proliferation of leukemia and lymphoma cells, particularly interactions with the tumour microenvironment which result in resistance to therapy. 

Multiple Myeloma Translational Research

Investigating key biological processes to develop novel therapeutic strategies for multiple myeloma. 

Synthetic Physiology

Protein engineering to understand and cure disease, such as establishing new methods to ‘remote control’ the signaling pathways and consequently the behaviour of cancer cells, nerve cells and key cells linked to diabetes.

Systems Immunology/Biology

Using computational and experimental systems immunology methods to investigate how vaccines and microbes (pathogenic and commensal) modulate the immune system in a range of different contexts, including cancer.

Prostate Cancer

Characterising the mechanisms by which prostate tumours metastasise and become resistant to therapies, in order to develop new drugs and biomarkers for treatment and management. 

Renal

Examining the mechanism underlying compensatory renal hypertrophy, the translation and clinical relevance of urine diagnostics in cancer, and the molecular and cellular responses to oxygen. 

Cancer Prevention

Understanding health behaviours and using this knowledge to design, evaluate and scale up health behaviour change interventions for the primary and secondary prevention of chronic diseases such as cancer.

Health economics

Measuring and valuing health outcomes and care preferences associated with cancer.

Health systems

Using economic evaluation to inform decision-making within the health system and improve health outcomes and equity for cancer patients and surviors, such evaluating diagnostic pathways, treatment patterns, and specific care models.

National Centre for Education and Training on Addiction (NCETA)

Working to advance the capacity of health and human services organisations and workers to respond to alcohol and drug-related problems, reducing the incidence of chronic diseases such as cancer.

Survivorship

Seeking to improve health outcomes for cancer survivors through examination of burden of disability and unmet needs after cancer diagnosis, and development and implementation of new models of care for cancer patients and survivors.